A broad-spectrum anthelmintic
Related Products
Metabolite(s)
250215-hydroxy Thiabendazole
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Thiabendazole

Item No. 23391

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-thiazolyl)-1H-benzimidazole
CAS Number
148-79-8
Synonyms
  • NSC 90507
  • NSC 525040
  • TBZ
  • Tiabendazole
Molecular Formula
C10H7N3S
Formula Weight
201.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:20): 0.05 mg/mlEthanol: 0.5 mg/ml
λmax
243, 301 nm
SMILES
C12=CC=CC=C1NC(C3=CSC=N3)=N2
InChi Code
InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChi Key
WJCNZQLZVWNLKY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $37

    Add

    50 g

    $69

    Add

    100 g

    $128

    Add

    500 g

    $556

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Thiabendazole is a broad-spectrum anthelmintic that is active against a variety of helminths.1 In sheep, thiabendazole (50 mg/kg) kills greater than 95% of adult worms from ten genera, including Trichostrongylus, Cooperia, Nematodirus, Ostertagia, Haemonchus, Oesophagostomum, Bunostomum, Strongyloides, Chabertia, and Trichuris. It also inhibits production of eggs and disrupts larval development. Thiabendazole inhibits fumarate reductase in helminths, which inhibits succinate formation, and therefore energy production through the citric acid cycle.2 It also inhibits methionine aminopeptidase in E. coli (Ki = 40 nM; IC50 = 47.2 nM).3 Formulations containing thiabendazole have been used in the control of parasitic infections in livestock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, H.D., Matzuk, A.R., Ilves, I.R., et al. Antiparasitic drugs. IV. 2-(4'-thiazolyl)-benzimidazole, a new anthelmintic. J. Am. Chem. Soc. 83(7), 1764-1765 (1961).

    2. Criado Fornelio, A., Rodriguez Caabeiro, F., and Jimenez Gonzalez, A. The mode of action of some benzimidazole drugs on Trichinella spiralis. Parasitology 95(pt 1), 61-70 (1987).

    3. Schiffmann, R., Neugebauer, A., and Klein, C.D. Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J. Med. Chem. 49(2), 511-522 (2006).