A Mas receptor antagonist
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A-779 (trifluoroacetate salt)

Item No. 23396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-isoleucine-7-D-alanine-1-7-angiotensin II, trifluoroacetate salt
Molecular Formula
C39H60N12O11 • XCF3COOH
Formula Weight
873.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 33 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)N[C@]([H])(C(N[C@@H](CC2=CNC=N2)C(N[C@@H](C(O)=O)C)=O)=O)[C@H](CC)C.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C39H60N12O11.C2HF3O2/c1-6-20(4)31(37(60)49-28(15-23-17-43-18-45-23)34(57)46-21(5)38(61)62)51-35(58)27(14-22-9-11-24(52)12-10-22)48-36(59)30(19(2)3)50-33(56)26(8-7-13-44-39(41)42)47-32(55)25(40)16-29(53)54;3-2(4,5)1(6)7/h9-12,17-21,25-28,30-31,52H,6-8,13-16,40H2,1-5H3,(H,43,45)(H,46,57)(H,47,55)(H,48,59)(H,49,60)(H,50,56)(H,51,58)(H,53,54)(H,61,62)(H4,41,42,44);(H,6,7)/t20-,21+,25-,26-,27-,28-,30-,31-;/m0./s1
InChi Key
KEBJQEFOFJTHSC-VLIPIWRHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay).1 It does not compete with angiotensin 1 (AT1) and AT2 receptor agonists for binding in adrenocortical membranes when used at a concentration of 1 µM and exhibits an IC50 value greater than 10 µM in adrenomedullary membranes.2 In vitro, A-779 inhibits Ang (1-7)-induced release of arachidonic acid from CHO cells transfected with Mas.1 A-779 (0.01 mg/kg) prevents the antidiuretic effects of Ang (1-7) in water-loaded rats. It also inhibits the Ang (1-7)-induced decrease in mean arterial pressure (MAP) when administered by microinjection into the nucleus of the solitary tract with no effect on basal MAP. A-779 increases urine flow rate and sodium excretion in male, but not female, rats when AT1 and AT2 receptors are blocked by the selective antagonists losartan (Item No. 10006594) and PD 123319 (Item No. 16099), respectively.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santos, R.A., Simoes e Silva, A.C., Maric, C., et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl. Acad. Sci. USA 100(14), 8258-8263 (2003).

    2. Santos, R.A., Campagnole-Santos, M.J., Baracho, N.C., et al. Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): Evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res. Bull. 35(4), 293-298 (1994).

    3. Mansoori, A.O., S., and Nematbakhsh, M. Role of Mas receptor antagonist (A779) on pressure diuresis and natriuresis and renal blood flow in the absence of angiotensin II receptors type 1 and 2 in female and male rats. J. Physiol. Pharmacol. 65(5), 633-639 (2014).