A partial antagonist of CXCR4
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MSX-122

Item No. 23426

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N4-di-2-pyrimidinyl-1,4-benzenedimethanamine
CAS Number
897657-95-3
Molecular Formula
C16H16N6
Formula Weight
292.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.2 mg/mlDMSO: 0.2 mg/ml
λmax
239, 302 nm
SMILES
C1(NCC2=CC=C(CNC3=NC=CC=N3)C=C2)=NC=CC=N1
InChi Code
InChI=1S/C16H16N6/c1-7-17-15(18-8-1)21-11-13-3-5-14(6-4-13)12-22-16-19-9-2-10-20-16/h1-10H,11-12H2,(H,17,18,21)(H,19,20,22)
InChi Key
PXZXYRKDDXKDTK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Cayman Chemical
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    Product Description

    MSX-122 is a small molecule partial antagonist of C-X-C chemokine 4 (CXCR4; IC50 = ~10 nM).1 It reduces inflammation and infiltration of CXCR4+ cells in a dextran sulfate (Item No. 23250) model of experimental colitis in mice. Specifically, it prevents the production of TNF-α, IL-1β, and IL-6. MSX-122 also reduces TNF-α secretion by macrophages infected with patient-derived invasive E. coli. It decreases metastases in mouse models utilizing MDA-MB-231 breast cancer or 686LN-Ms squamous cell carcinoma cells injected intravenously or OMM2.3 melanoma cells inoculated into the eye.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, Z., Zhan, W., Zhu, A., et al. Development of a unique small molecule modulator of CXCR4. PloS One 7(4), e34038 (2012).