A JAK1 inhibitor
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Solcitinib

Item No. 23439

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-[4-[(3,3-dimethyl-1-azetidinyl)carbonyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide
CAS Number
1206163-45-2
Synonyms
  • GLPG0778
  • GSK2586184
Molecular Formula
C22H23N5O2
Formula Weight
389.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
λmax
201, 231, 303 nm
SMILES
O=C(N1CC(C)(C)C1)C2=CC=C(C3=CC=CC4=NC(NC(C5CC5)=O)=NN43)C=C2
InChi Code
InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)
InChi Key
MPYACSQFXVMWNO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    Solcitinib is a JAK1 inhibitor (IC50 = 9.8 nM).1 It is greater than 10-fold selective for JAK1 over JAK2, JAK3, and TYK2.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ludbrook, V.J., Hicks, K.J., Hanrott, K.E., et al. Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study. Br. J. Dermatol. 174(5), 985-995 (2016).