An IL-5 receptor antagonist
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YM-90709

Item No. 23448

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-benz[7,8]indolizino[2,3-b]quinoxaline
CAS Number
163769-88-8
Molecular Formula
C22H21N3O2
Formula Weight
359.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/ml
λmax
229, 246, 282, 383 nm
SMILES
COC1=C(OC)C=C(C2=CC3=NC4=CC=CC=C4N=C3N2C(C)(C)C5)C5=C1
InChi Code
InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
InChi Key
HIXSPVQXXDULHS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $402

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    Cayman Chemical
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    Product Description

    YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 µM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay.1 It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 µM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morokata, T., Ida, K., and Yamada, T. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int. Immunopharmacol. 2(12), 1693-1702 (2002).

    2. Morokata, T., Suzuki, K., Ida, K., et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int. Immunopharmacol. 4(7), 873-883 (2004).

    3. Morokata, T., Suzuki, K., Ida, K., et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol. Lett. 98(1), 161-165 (2005).