A negative control for JAK3 inhibition
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Isomer(s)
42263LY456236 (hydrochloride)
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WHI-P258

Item No. 23453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dimethoxy-N-phenyl-4-quinazolinamine
CAS Number
21561-09-1
Molecular Formula
C16H15N3O2
Formula Weight
281.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 15 mg/ml
λmax
201, 223, 254, 346 nm
SMILES
COC1=C(OC)C=C(C(NC2=CC=CC=C2)=NC=N3)C3=C1
InChi Code
InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
InChi Key
MJKCGAHOCZLYDG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $82

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    10 mg

    $130

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    25 mg

    $223

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    Product Description

    WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 µM.1 However, it is inactive at JAK3 (IC50 = >300 µM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sudbeck, E.A., Liu, X.P., Narla, R.K., et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin. Cancer Res. 5(6), 1569-1582 (1999).

    2. Yakota, S.-i., Yokosawa, N., Okabayashi, T., et al. Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication. Virology 338(1), 173-181 (2005).

    3. Tibbles, H.E., Vassilev, A., Wendorf, H., et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. The Journal of Biological Chemisty 276(21), 17815-17822 (2001).