An inhibitor of VEGFRs
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NVP-ACC789

Item No. 23458

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
CAS Number
300842-64-2
Molecular Formula
C21H17BrN4
Formula Weight
405.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMF:PBS (pH 7) (1:10): 0.09 mg/mlDMSO: 1 mg/mlEthanol: 0.2 mg/ml
λmax
215, 337 nm
SMILES
BrC1=CC(NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42)=CC=C1C
InChi Code
InChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)
InChi Key
GXWKSXUPEFVUOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    NVP-ACC789 is an inhibitor of VEGF receptor tyrosine kinases (VEGFRs; IC50s = 0.38, 0.02, 0.18, and 0.23 μM for human VEGFR1, 2, 3, and mouse Vegfr2, respectively).1 It is selective for VEGFRs over FGFRs and PDGFRα (IC50s = >10 μM) but has activity at PDGFRβ (IC50 = 1.4 μM) in an enzyme assay. NVP-ACC789 inhibits VEGF-induced VEGFR2 autophosphorylation (IC50 = 11.5 nM in CHO cells transfected with the human receptor). It also inhibits VEGF- and bFGF-induced angiogenesis and cell migration of BAE and BME cells. In vivo, NVP-ACC789 blocks bFGF- and VEGF-induced angiogenesis (ED50s = 9 and 26 mg/kg, respectively) in a mouse model of growth factor-induced angiogenesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tille, J.C., Wood, J., Mandriota, S.J., et al. Vascular endothelial growth factor (VEGF) receptor-2 antagonists inhibit VEGF- and basic fibroblast growth factor-induced angiogenesis in vivo and in vitro. J. Pharmacol. Exp. Ther. 299(3), 1073-1085 (2001).