An antibiotic
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Labeled Version(s)
33296Nitrofurantoin-13C3
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Nitrofurantoin

Item No. 23510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione
CAS Number
67-20-9
Synonyms
  • NSC 2107
  • NSC 44150
Molecular Formula
C8H6N4O5
Formula Weight
238.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.5 mg/mlEthanol: 15 mg/ml
λmax
268, 363 nm
SMILES
O=C(NC(C1)=O)N1/N=C/C2=CC=C([N+]([O-])=O)O2
InChi Code
InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+
InChi Key
NXFQHRVNIOXGAQ-YCRREMRBSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Nitrofurantoin is an antibiotic.1 In vivo, nitrofurantoin (25-100 mg/kg, i.m.) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection.2 Formulations containing nitrofurantoin have been used to treat urinary tract infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rocha, H., Da Silva Teles, E., and Barros, M. Site of action of nitrofurantoin in experimental urinary tract infection. Appl. Microbiol. 18(4), 547-549 (1969).

    2. Hossack, D.J.N. Proteus vulgaris urinary tract infections in rats; treatment with nitrofuran derivatives. Br. J. Pharmacol. Chemother. 19(2), 306-312 (1962).