An internal standard for the quantification of nitrofurantoin
Related Products
Unlabeled Version(s)
23510Nitrofurantoin
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Nitrofurantoin-13C3

Item No. 33296

Technical Information
Formal Name
1-[[(5-nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione-13C3
CAS Number
1217226-46-4
Molecular Formula
C5[13C]3H6N4O5
Formula Weight
Purity
≥95%
A solid
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=[13C](N[13C]([13CH2]1)=O)N1/N=C/C2=CC=C([N+]([O-])=O)O2
InChi Code
InChI=1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+/i4+1,6+1,8+1
InChi Key
NXFQHRVNIOXGAQ-PZGYLZBDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Nitrofurantoin-13C3 is intended for use as an internal standard for the quantification of nitrofurantoin (Item No. 23510) by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1 In vivo, nitrofurantoin (25-100 mg/kg) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as calculi and abscess formation, in a rat model of P. vulgaris urinary tract infection.2 Formulations containing nitrofurantoin have been used to treat urinary tract infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rocha, H., Da Silva Teles, E., and Barros, M. Site of action of nitrofurantoin in experimental urinary tract infection. Appl. Microbiol. 18(4), 547-549 (1969).

    2. Hossack, D.J.N. Proteus vulgaris urinary tract infections in rats; treatment with nitrofuran derivatives. Br. J. Pharmacol. Chemother. 19(2), 306-312 (1962).