A melatonin receptor agonist
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Labeled Version(s)
31771Tasimelteon-d5
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Tasimelteon

Item No. 23546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-propanamide
CAS Number
609799-22-6
Synonyms
  • BMS 214778
Molecular Formula
C15H19NO2
Formula Weight
245.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
287 nm
SMILES
O=C(CC)NC[C@@H]1C[C@H]1C2=C3C(OCC3)=CC=C2
InChi Code
InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1
InChi Key
PTOIAAWZLUQTIO-GXFFZTMASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $37

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    10 mg

    $70

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    25 mg

    $92

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    50 mg

    $163

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    Product Description

    Tasimelteon is a melatonin (MT) receptor agonist.1 It selectively binds MT1 and MT2 receptors (Kis = 0.304 and 0.069 nM, respectively, in NIH3T3 cells expressing the recombinant human receptors) over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lavedan, C., Forsberg, M., and Gentile, A.J. Tasimelteon: A selective and unique receptor binding profile. Neuropharmacology 91, 142-147 (2015).