An internal standard for the quantification of tasimelteon
Related Products
Unlabeled Version(s)
23546Tasimelteon
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tasimelteon-d5

Item No. 31771

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-propanamide-2,2,3,3,3-d5
CAS Number
1962124-51-1
Synonyms
  • BMS 214778-d5
Molecular Formula
C15H14D5NO2
Formula Weight
250.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMF: solubleDMSO: solubleMethanol: soluble
SMILES
O=C(C([2H])([2H])C([2H])([2H])[2H])NC[C@@H]1C[C@@]1([H])C2=C3C(OCC3)=CC=C2
InChi Code
InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1/i1D3,2D2
InChi Key
PTOIAAWZLUQTIO-WILSWDKCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $202

    Add

    5 mg

    $897

    Add
    Product Description

    Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon (Item No. 23546) by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist.1 It selectively binds MT1 and MT2 receptors (Kis = 0.304 and 0.069 nM, respectively, in NIH3T3 cells expressing the recombinant human receptors) over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lavedan, C., Forsberg, M., and Gentile, A.J. Tasimelteon: A selective and unique receptor binding profile. Neuropharmacology 91, 142-147 (2015).