A thiazide diuretic
Related Products
Labeled Version(s)
31608Hydroflumethiazide-13C-d2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Hydroflumethiazide

Item No. 23612

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide
CAS Number
135-09-1
Synonyms
  • NSC 44627
Molecular Formula
C8H8F3N3O4S2
Formula Weight
331.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=S1(C2=C(C=C(C(F)(F)F)C(S(N)(=O)=O)=C2)NCN1)=O
InChi Code
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChi Key
DMDGGSIALPNSEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $134

    Add

    100 mg

    $213

    Add
    Product Description

    Hydroflumethiazide is a thiazide diuretic that also inhibits carbonic anhydrase (CA).1 It is selective for CAII, VB, VII, IX, XII, and XIV (Kis = 305-235 nM) over CAI, IV, and VI (Kis = 2,840-8,250 nM) and CAIII, VA, and XIII (Kis = >10 µM). Diuretics of the thiazide class, of which hydroflumethiazide is a member, inhibit the renal Na+/Cl- cotransporter.2 Formulations containing hydroflumethiazide have been used as diuretics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Temperini, C., Cecchi, A., Scozzafava, A., et al. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg. Med. Chem. Lett. 18(8), 2567-2573 (2008).

    2. Hughes, A.D. How do thiazide and thiazide-like diuretics lower blood pressure? J. Renin Angiotensin Aldosterone Syst. 5(4), 155-160 (2004).