An internal standard for the quantification of hydroflumethiazide
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Unlabeled Version(s)
23612Hydroflumethiazide
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Hydroflumethiazide-13C-d2

Item No. 31608

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide-3-13C-3,3-d2 1,1-dioxide
CAS Number
1189877-11-9
Molecular Formula
C7[13C]H6D2F3N3O4S2
Formula Weight
334.3
Purity
≥99% deuterated forms (d1-d2)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=S1(C2=C(C=C(C(F)(F)F)C(S(N)(=O)=O)=C2)N[13C]([2H])([2H])N1)=O
InChi Code
InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)/i3+1D2
InChi Key
DMDGGSIALPNSEE-QFNKQLDQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $369

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    Product Description

    Hydroflumethiazide-13C-d2 is intended for use as an internal standard for the quantification of hydroflumethiazide (Item No. 23612) by GC- or LC-MS. Hydroflumethiazide is a thiazide diuretic and an inhibitor of carbonic anhydrase (CA).1 It is selective for CAII, CAVB, CAVII, CAIX, CAXII, and CAXIV (Kis = 0.24-0.31 µM) over CAI, CAIV, and CAVI (Kis = 2.8-8.3 µM), as well as CAIII, CAVA, and CAXIII (Kis = >10 µM). Formulations containing hydroflumethiazide have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Temperini, C., Cecchi, A., Scozzafava, A., et al. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg. Med. Chem. Lett. 18(8), 2567-2573 (2008).