A broad-spectrum antibiotic
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Alternative(s)
35535Fosfomycin (calcium salt)
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Fosfomycin Trometamol

Item No. 23632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[(2R,3S)-3-methyl-2-oxiranyl]-phosphonic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
CAS Number
78964-85-9
Synonyms
  • Fosfomycin Tromethamine
Molecular Formula
C4H11NO3 • C3H7O4P
Formula Weight
259.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly solubleWater: Soluble
SMILES
C[C@H]1[C@@H](P(O)(O)=O)O1.OCC(CO)(N)CO
InChi Code
InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/m.0/s1
InChi Key
QZJIMDIBFFHQDW-LMLSDSMGSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $41

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    10 mg

    $72

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    25 mg

    $235

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    Cayman Chemical
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    Product Description

    Fosfomycin trometamol is a broad-spectrum antibiotic that is active against Gram-negative and Gram-positive bacteria with MIC90 values of 8, 32, 4, and 32 µg/mL for ESBL E. coli, carbapenemase-producing K. pneumoniae, P. mirabilis, and methicillin-resistant S. saprophyticus, respectively, in a broth microdilution assay.1 It is an inhibitor of uridine diphospho-N-acetyl-D-glucosamine enolpyruvyl transferase (MurA) that enters cells via the glycerol-3-phosphate and hexose-6-phosphate transporters.2,3 Formulations containing fosfomycin trometamol have been used in the treatment of urinary tract infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mezzatesta, M.L., La Rosa, G., Maugeri, G., et al. In vitro activity of fosfomycin trometamol and other oral antibiotics against multi-drug-resistant uropathogens. Int. J. Antimicrob. Agents 49(6), 763-766 (2017).

    2. Kahan, F.M., Kahan, J.S., Cassidy, P.J., et al. The mechanism of action of fosfomycin (phosphonomycin). Ann. N. Y. Acad. Sci. 235(0), 364-386 (1974).

    3. Santoro, A., Cappello, A.R., Madeo, M., et al. Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coli. Biochim. Biophys. Acta 1810(12), 1323-1329 (2011).