An antibiotic
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Cellocidin

Item No. 23637

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butynediamide
CAS Number
543-21-5
Synonyms
  • Acetylenedicarboxylic Acid
  • NSC 38643
  • NSC 65381
Molecular Formula
C4H4N2O2
Formula Weight
112.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
212 nm
SMILES
NC(C#CC(N)=O)=O
InChi Code
InChI=1S/C4H4N2O2/c5-3(7)1-2-4(6)8/h(H2,5,7)(H2,6,8)
InChi Key
JBTGHKUTYAMZEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $172

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    25 mg

    $374

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    50 mg

    $695

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    Cayman Chemical
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    Product Description

    Cellocidin is an antibiotic originally isolated from S. chibaensis.1 It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively).1,2 It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus.3 Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, S., Nakamura, G., Okuma, K., et al. Cellocidin, a new antibiotic. J. Antibiot. (Tokyo) 11(3), 81-83 (1958).

    2. Otoguro, K., Ishiyama, A., Namatame, M., et al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J. Antibiot. (Tokyo) 61(6), 372-378 (2008).

    3. Dzeng, R.K., Jha, H.C., Lu, J., et al. Small molecule growth inhibitors of human oncogenic gammaherpesvirus infected B-cells. Mol. Oncol. 9(2), 365-376 (2015).

    4. Misato, T. Mode of action of agricultural antibiotics developed in Japan. Residue Rev. 25, 93-106 (1969).