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Desogestrel

Item № 23651
CAS № 54024-22-5
Purity ≥95%
product image
                (CAS 54024-22-5)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $48.00 0.00
     10 mg $86.00 0.00
     25 mg $132.00 0.00

Pricing updated 2019-05-23. Prices are subject to change without notice.

Description
Synonyms
  • ORG 2969

Desogestrel is a synthetic progestogen.1 It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.2 Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.2,3

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Technical Information
Formal Name
(17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
CAS Number
54024-22-5
Synonyms
  • ORG 2969
Molecular Formula
C22H30O
Formula Weight
310.5
Purity
≥95%
Formulation
A solid
SMILES
O[C@@]1(C#C)CC[C@@]([C@]1(CC)C2)([H])[C@]3([H])CCC4=CCCC[C@]4([H])[C@@]3([H])C2=C
InChI Code
InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
InChI Key
RPLCPCMSCLEKRS-BPIQYHPVSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. van der Vies, J., and de Visser, J. Endocrinological studies with desogestrel Arzneimittelforschung 33(2), 231-236 (1983).

2. Fröhlich, M., Albermann, N., Sauer, A., et al. In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins Biochem. Pharmacol. 68(12), 2409-2416 (2004).

3. Amiri, M., Nahidi, F., Khalili, D., et al. Comparing the effects of oral contraceptives containing levonorgestrel with products containing antiandrogenic progestins on clinical, hormonal, and metabolic parameters and quality of life in women with polycystic ovary syndrome: Crossover randomized controlled trial protocol JMIR Res. Protoc. 6(9), e191 (2017).

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