Pricing updated 2019-05-23. Prices are subject to change without notice.
Desogestrel is a synthetic progestogen.1 It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner.2 Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.2,3
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1. van der Vies, J., and de Visser, J. Endocrinological studies with desogestrel Arzneimittelforschung 33(2), 231-236 (1983).
Fröhlich, M., Albermann, N., Sauer, A., et al. In vitro and ex vivo evidence for modulation of P-
3. Amiri, M., Nahidi, F., Khalili, D., et al. Comparing the effects of oral contraceptives containing levonorgestrel with products containing antiandrogenic progestins on clinical, hormonal, and metabolic parameters and quality of life in women with polycystic ovary syndrome: Crossover randomized controlled trial protocol JMIR Res. Protoc. 6(9), e191 (2017).