A sodium channel blocker
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Active Metabolite(s)
35008Eslicarbazepine
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Eslicarbazepine Acetate

Item No. 23656

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(10S)-10-(acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
236395-14-5
Synonyms
  • BIA 2-093
Molecular Formula
C17H16N2O3
Formula Weight
296.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMSO: 5mg/mLEthanol: 10mg/mL
SMILES
O=C(C)O[C@@H]1C2=C(C=CC=C2)N(C(N)=O)C3=C(C=CC=C3)C1
InChi Code
InChI=1S/C17H16N2O3/c1-11(20)22-16-10-12-6-2-4-8-14(12)19(17(18)21)15-9-5-3-7-13(15)16/h2-9,16H,10H2,1H3,(H2,18,21)/t16-/m0/s1
InChi Key
QIALRBLEEWJACW-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    Product Description

    Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay).1 It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 μM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against seizures induced by maximal electroshock (MES) in mice with ED50 values of 4.7 and 6.3 mg/kg, respectively, which are well below the median toxic dose (TD50) values of 358.7 and 78.6 mg/kg for oral and i.p. administration respectively. High-dose administration (30 mg/kg) of eslicarbazepine acetate prevents picrotoxin-induced seizures in rats.2 Low-dose administration (10 mg/kg) does not suppress picrotoxin-induced seizures, however, it reduces seizure number and duration. Formulations containing eslicarbazepine acetate have been used for the treatment of partial-onset seizures.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benes, J., Parada, A., Figueiredo, A.A., et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J. Med. Chem. 42(14), 2582-2587 (1999).

    2. Sierra-Paredes, G., Núñez-Rodriguez, A., Vázquez-López, A., et al. Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats. Epilepsy Res. 72(2-3), 140-146 (2006).

    3. Toledano, R., Jovel, C.E., Jiménez-Huete, A., et al. Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: Experience from a multicenter, observational study. Epilepsy Behav. 73, 173-179 (2017).