A substrate for OAT1, NPT1, and MDR2
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4-Aminohippuric Acid

Item No. 23726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-aminobenzoyl)-glycine
CAS Number
61-78-9
Synonyms
  • p-Aminohippuric Acid
  • para-Aminohippuric Acid
  • NSC 7550
  • NSC 13064
Molecular Formula
C9H10N2O3
Formula Weight
194.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH7.2) (1:30): 0.03 mg/mlDMSO: 20 mg/ml
λmax
283 nm
SMILES
NC1=CC=C(C(NCC(O)=O)=O)C=C1
InChi Code
InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
InChi Key
HSMNQINEKMPTIC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $41

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    10 g

    $75

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    Product Description

    4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 µM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 µM in HEK293 cells).1,2,3 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid (Item No. 18659). Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sekine, T., Watanabe, N., Hosoyamada, M., et al. Expression cloning and characterization of a novel multispecific organic anion transporter. The Journal of Biological Chemisty 272(30), 18526-18529 (1997).

    2. Uchino, H., Tamai, I., Yamashita, K., et al. p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem. Biophys. Res. Commun. 270(1), 254-259 (2000).

    3. Leier, I., Hummel-Eisenbeiss, J., Cui, Y., et al. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 57(4), 1636-1642 (2000).