A substrate for OAT1, NPT1, and MDR2
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

4-Aminohippuric Acid

Item No. 23726

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-aminobenzoyl)-glycine
CAS Number
61-78-9
Synonyms
  • p-Aminohippuric Acid
  • para-Aminohippuric Acid
  • NSC 7550
  • NSC 13064
Molecular Formula
C9H10N2O3
Formula Weight
194.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH7.2) (1:30): 0.03 mg/mlDMSO: 20 mg/ml
λmax
283 nm
SMILES
NC1=CC=C(C(NCC(O)=O)=O)C=C1
InChi Code
InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13)
InChi Key
HSMNQINEKMPTIC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 g

    $41

    Add

    10 g

    $75

    Add
    Product Description

    4-Aminohippuric acid is a substrate for various renal transporters that has been used in the study of anion uptake in the kidney. It is a substrate for organic anion transporter 1 (OAT1; Km = 14.3 µM in X. laevis oocytes), the human inorganic phosphate transporter (NPT1; Km = 2.66 mM in HEK293 cells), and apical multidrug resistance protein (MDR2; Km = 880 µM in HEK293 cells).1,2,3 4-Aminohippuric acid is a glycine amide form of 4-aminobenzoic acid (Item No. 18659). Formulations containing 4-aminohippuric acid have been used as markers to determine renal plasma flow.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sekine, T., Watanabe, N., Hosoyamada, M., et al. Expression cloning and characterization of a novel multispecific organic anion transporter. The Journal of Biological Chemisty 272(30), 18526-18529 (1997).

    2. Uchino, H., Tamai, I., Yamashita, K., et al. p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. Biochem. Biophys. Res. Commun. 270(1), 254-259 (2000).

    3. Leier, I., Hummel-Eisenbeiss, J., Cui, Y., et al. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 57(4), 1636-1642 (2000).