A prodrug form of tedizolid
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Active Metabolite(s)
32952Tedizolid
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Tedizolid Phosphate

Item No. 23729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone
CAS Number
856867-55-5
Synonyms
  • TR-701 FA
Molecular Formula
C17H16FN6O6P
Formula Weight
450.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
300 nm
SMILES
FC1=C(C2=CN=C(C3=NN(C)N=N3)C=C2)C=CC(N4C(O[C@@H](COP(O)(O)=O)C4)=O)=C1
InChi Code
InChI=1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1
InChi Key
QCGUSIANLFXSGE-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Tedizolid phosphate is a prodrug form of tedizolid, an antibiotic with activity against Gram-positive bacteria.1 Tedizolid phosphate is rapidly converted by non-specific phosphatases to tedizolid, which inhibits the growth of S. aureus, S. epidermidis, E. faecalis, E. faecium, S. pneumoniae, and S. pyogenes (MICs = 0.25-1 μg/ml). In vivo, tedizolid phosphate (15 mg/kg) reduces vegetation titer in a rabbit model of aortic valve endocarditis caused by methicillin-resistant S. aureus (MRSA).2 It also reduces densities of methicillin-susceptible S. aureus and MRSA infection in a mouse model of catheter-related biofilm infection and increases survival in a rabbit model of MRSA necrotizing pneumonia.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ong, V., Flanagan, S., Fang, E., et al. Absorption, distribution, metabolism, and excretion of the novel antibacterial prodrug tedizolid phosphate. Drug Metab. Dispos. 42(8), 1275-1284 (2014).

    2. Chan, L.C., Basuino, L., Dip, E.C., et al. Comparative efficacies of tedizolid phosphate, vancomycin, and daptomycin in a rabbit model of methicillin-resistant Staphylococcus aureus endocarditis. Antimicrob. Agents Chemother. 59(6), 3252-3256 (2015).

    3. Bayer, A.S., Abdelhady, W., Li, L., et al. Comparative efficacies of tedizolid phosphate, linezolid, and vancomycin in a murine model of subcutaneous catheter-related biofilm infection due to methicillin-susceptible and -sesistant Staphylococcus aureus. Antimicrob. Agents Chemother. 60(8), 5092-5096 (2016).

    4. Le, V.T.M., Le, H.N., Pinheiro, M.G., et al. Effects of tedizolid phosphate on survival outcomes and suppression of production of staphylococcal toxins in a rabbit model of methicillin-resistant Staphylococcus aureus necrotizing pneumonia. Antimicrob. Agents Chemother. 61(4), e02734-02716 (2017).