An oxazolidinone antibiotic
Related Products
Labeled Version(s)
33290Tedizolid-13C-d3
Pro-drug Form(s)
23729Tedizolid Phosphate
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Tedizolid

Item No. 32952

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5R)-3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-2-oxazolidinone
CAS Number
856866-72-3
Synonyms
  • DA 7157
  • TR-700
Molecular Formula
C17H15FN6O3
Formula Weight
370.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly soluble
λmax
234, 302 nm
SMILES
FC1=C(C2=CN=C(C3=NN(C)N=N3)C=C2)C=CC(N4C[C@H](CO)OC4=O)=C1
InChi Code
InChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
InChi Key
XFALPSLJIHVRKE-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

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    50 mg

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    Product Description

    Tedizolid is an oxazolidinone antibiotic and active metabolite of the antibiotic tedizolid phosphate (Item No. 23729).1 Tedizolid phosphate is converted to tedizolid by phosphatases in vivo. It is active against a wide variety of clinical isolates, including isolates of methicillin-resistant S. aureus (MRSA), E. faecalis, and penicillin-susceptible S. pneumoniae (MICs = 0.5, 0.5, and 0.25 µg/ml, respectively), as well as isolates of anaerobic bacteria (MICs = 0.25-4 µg/ml). Tedizolid protects against mortality in a mouse model of systemic methicillin-susceptible S. aureus (MSSA) infection (ED50 = 8.8 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schaadt, R., Sweeney, D.A., Shinabarger, D., et al. In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. Antimicrob. Agents Chemother. 53(8), 3236-3239 (2009).

    2. Im, W.B., Choi, S.H., Park, J.-Y., et al. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. Eur. J. Med. Chem. 46(4), 1027-1039 (2011).