A DNA alkylating agent
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Labeled Version(s)
26774Chlorambucil-d8
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Chlorambucil

Item No. 23744

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[bis(2-chloroethyl)amino]-benzenebutanoic acid
CAS Number
305-03-3
Synonyms
  • CB-1348
  • NCI 3088
  • NSC 3088
Molecular Formula
C14H19Cl2NO2
Formula Weight
304.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleMethanol: Slightly soluble
SMILES
OC(CCCC1=CC=C(N(CCCl)CCCl)C=C1)=O
InChi Code
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChi Key
JCKYGMPEJWAADB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $36

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    1 g

    $90

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    Cayman Chemical
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    Product Description

    Chlorambucil is a DNA alkylating agent.1 It induces DNA cross-linking in vitro when used at a concentration of 1 mg/ml and preferentially targets guanine-rich regions. Chlorambucil (8 and 15 mg/kg) is teratogenic in vivo, reducing fetal brain size and inducing microcephaly when administered to pregnant mice.2 Formulations containing chlorambucil have been used in the treatment of various cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mohamed, D., Mowaka, S., Thomale, J., et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem. Res. Toxicol. 22(8), 1435-1446 (2009).

    2. Tanaka, O., Yoshioka, N., Yoshioka, T., et al. Effects of chlorambucil on the brain development in mice during post-neurulation period. Congenit. Anom. (Kyoto) 31(3), 141-152 (1991).