An internal standard for the quantification of chlorambucil
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Unlabeled Version(s)
23744Chlorambucil
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Chlorambucil-d8

Item No. 26774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[bis(2-chloroethyl)amino-d8]-benzenebutanoic acid
CAS Number
2748247-26-7
Molecular Formula
C14H11D8Cl2NO2
Formula Weight
312.3
Purity
≥99% deuterated forms (d1-d8)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
OC(CCCC1=CC=C(N(C([2H])([2H])C([2H])([2H])Cl)C([2H])([2H])C([2H])([2H])Cl)C=C1)=O
InChi Code
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)/i8D2,9D2,10D2,11D2
InChi Key
JCKYGMPEJWAADB-JNJBWJDISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $103

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    1 mg

    $194

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    Cayman Chemical
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    Product Description

    Chlorambucil-d8 is intended for use as an internal standard for the quantification of chlorambucil (Item No. 23744) by GC- or LC-MS. Chlorambucil is a DNA alkylating agent.1 It induces DNA cross-linking in vitro when used at a concentration of 1 mg/ml and preferentially targets guanine-rich regions. Chlorambucil (8 and 15 mg/kg) is teratogenic in vivo, reducing fetal brain size and inducing microcephaly when administered to pregnant mice.2 Formulations containing chlorambucil have been used in the treatment of various cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mohamed, D., Mowaka, S., Thomale, J., et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem. Res. Toxicol. 22(8), 1435-1446 (2009).

    2. Tanaka, O., Yoshioka, N., Yoshioka, T., et al. Effects of chlorambucil on the brain development in mice during post-neurulation period. Congenit. Anom. (Kyoto) 31(3), 141-152 (1991).