A selective estrogen receptor modulator
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Labeled Version(s)
33465Ospemifene-d4
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Ospemifene

Item No. 23755

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol
CAS Number
128607-22-7
Synonyms
  • FC-1271a
Molecular Formula
C24H23ClO2
Formula Weight
378.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1.5 mg/ml
λmax
240, 282 nm
SMILES
ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCO)C=C2)\C3=CC=CC=C3
InChi Code
InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
InChi Key
LUMKNAVTFCDUIE-VHXPQNKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    100 mg

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    250 mg

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    500 mg

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    Product Description

    Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).1 It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol (Item No. 10006315) in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Unkila, M., Kari, S., Yatkin, E., et al. Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause. J. Steroid Biochem. Mol. Biol. 138, 107-115 (2013).