A β-adrenergic receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Carteolol (hydrochloride)

Item No. 23758

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone, monohydrochloride
CAS Number
51781-21-6
Synonyms
  • NSC 300906
  • OPC 1085
Molecular Formula
C16H24N2O3 • HCl
Formula Weight
328.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 16 mg/mlEthanol: 11 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
217, 251 nm
SMILES
O=C1CCC2=C(OCC(CNC(C)(C)C)O)C=CC=C2N1.Cl
InChi Code
InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H
InChi Key
FYBXRCFPOTXTJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $75

    Add

    50 mg

    $134

    Add

    100 mg

    $252

    Add

    250 mg

    $553

    Add
    Product Description

    Carteolol is an antagonist of β-adrenergic receptors (Kd = 13 nM).1,2 It blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 µg/kg, respectively).3 The (R) and (S)-enantiomers of carteolol reduce intraocular pressure to similar levels in rabbits when applied topically as a 1% solution.4 Formulations containing carteolol have been used in the treatment of open-angle glaucoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takayanagi, I., Ogishima, M., Koike, K., et al. Dose difference in beta-adrenergic blockers with intrinsic sympathomimetic action to block beta-adrenoceptors and induce sympathomimetic action. Gen. Pharmacol. 20(4), 417-419 (1989).

    2. Gwathmey, J.K., Kim, C.S., Haijar, R.J., et al. Cellular and molecular remodeling in a heart failure model treated with the β-blocker carteolol. Am. J. Physiol. 276(5 Pt. 2), H1678-H1690 (1999).

    3. Yabuochi, Y., and Kinoshita, D. Cardiovascular studies of 5-(3-tert-butylamino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent β-adrenergic blocking agent. Jpn. J. Pharmacol. 24(6), 853-861 (1974).

    4. Takayanagi, I., Haiwara, H., Koike, K., et al. Effects of the R(+)- and S(−)-isomers of β-adrenoceptor blockers with intrinsic sympathomimetic activity, befunolol and carteolol, on rabbit intraocular pressure. Can. J. Physiol. Pharmacol. 69(8), 1243-1245 (1991).