Diazinon

Diazinon is an insecticide.¹ It is lethal to adult and larval beet webworms (LD₅₀s = 0.15 and 464 mg/kg, respectively).² Diazinon (0.5, 1, and 2 mg/kg) decreases isolated brainstem and forebrain choline acetyltransferase activity, a marker for neurological development, in neonatal rats.³ It is lethal to dogs when administered at doses ranging from 300-500 mg/kg.⁴ Diazinon (5-50 mg/kg) induces cardiac hemorrhage, increases fatty areas in the pancreas, as well as decreases the thickness of the duodenum and jejunum, in pigs. Formulations containing diazinon have been used in the control of ticks, lice, and flies in agriculture.

WARNING This product is not for human or veterinary use.

1. Earl, F.L., Melveger, B.E., Reinwall, J.E., et al. Diazinon toxicity-comparative studies in dogs and miniature swine. Toxicol. Appl. Pharmacol. 18(2), 285-295 (1971).

2. Leonova, I.N., and Slynko, N.M. Life stage variations in insecticidal susceptibility and detoxification capacity of the beet webworm, Pyrausta sticticalis L. (Lep., Pyralidae). J. Appl. Entomol. 128(6), 419-425 (2004).

3. Slotkin, T.A., Levin, E.D., and Seidler, F.J. Comparative developmental neurotoxicity of organophosphate insecticides: Effects on brain development are separable from systemic toxicity. Environ. Health Perspect. 114(5), 746-751 (2006).

4. Wang, X.-y., Gao, X.-m., Liu, H., et al. Gene expression profiling of the proliferative effect of periplocin on mouse cardiac microvascular endothelial cells. Chin. J. Integr. Med. 16(1), 33-40 (2010).