A muscarinic acetylcholine receptor antagonist
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Active Metabolite(s)
278335-hydroxymethyl Tolterodine (formate)
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Fesoterodine (fumarate)

Item No. 23777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-propanoic acid, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate
CAS Number
286930-03-8
Synonyms
  • SMP 8272
  • SPM 907
Molecular Formula
C26H37NO3 • C4H4O4
Formula Weight
527.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly SolubleWater: Slightly Soluble
SMILES
O=C(C(C)C)OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(CO)C=C1.OC(/C=C/C(O)=O)=O
InChi Code
InChI=1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1
InChi Key
MWHXMIASLKXGBU-RNCYCKTQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $80

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    10 mg

    $109

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    Product Description

    Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively).1 In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ney, P., Pandita, R.K., Newgreen, D.T., et al. Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivo. BJU Int. 101(8), 1036-1042 (2008).

    2. Biardeau, X., Przydacz, M., Aharony, S., et al. Early fesoterodine fumarate administration prevents neurogenic detrusor overactivity in a spinal cord transected rat model. PLoS One 12(1), e0169694 (2017).