An antagonist of muscle-type nAChRs
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Pancuronium (bromide hydrate)

Item No. 23778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-piperidinium], dibromide, hydrate
Synonyms
  • NSC 293162
Molecular Formula
C35H60N2O4 • 2Br [XH2O]
Formula Weight
732.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C(C)O[C@H]1[C@@H]([N+]2(C)CCCCC2)C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](OC(C)=O)[C@@H]([N+]6(C)CCCCC6)C[C@]5(C)[C@@]4([H])CC[C@@]31C.[Br-].[Br-].O
InChi Code
InChI=1S/C35H60N2O4.2BrH.H2O/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;;/h26-33H,7-23H2,1-6H3;2*1H;1H2/q+2;;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;;/m0.../s1
InChi Key
KSNRANIFOPUVTD-CVPFSWIZSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $36

    Add

    10 mg

    $63

    Add

    25 mg

    $135

    Add
    Product Description

    Pancuronium is an aminosteroid antagonist of muscle-type nicotinic acetylcholine receptors (nAChRs) with an IC50 value of 14.8 nM using patch clamp electrophysiology in BOSC23 cells expressing mouse nAChRs.1 It acts as a non-depolarizing neuromuscular blocking agent.2 Pancuronium enhances anesthesia induced by isoflurane (Item No. 23989), reducing immobilization with an ED50 value of 1.62 µg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, M., and Dilger, J.P. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Mol. Pharmacol. 75(1), 166-173 (2009).

    2. Buckett, W.R., Marjoribanks, C.E., Marwick, F.A., et al. The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. Br. J. Pharmacol. Chemother. 32(3), 671-682 (1968).

    3. Miyazaki, Y., Sunaga, H., Hobo, S., et al. Pancuronium enhances isoflurane anesthesia in rats via inhibition of cerebral nicotinic acetylcholine receptors. J. Anesth. 30(4), 671-676 (2016).