A dopamine decarboxylase inhibitor
Related Products
Labeled Version(s)
34884Carbidopa-d3 (hydrate)
Pro-drug Form(s)
43930Foscarbidopa
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Carbidopa (hydrate)

Item No. 23783

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-α-hydrazinyl-3,4-dihydroxy-α-methyl-benzenepropanoic acid, monohydrate
CAS Number
38821-49-7
Molecular Formula
C10H14N2O4 • H2O
Formula Weight
244.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
OC1=C(O)C=CC(C[C@](C)(NN)C(O)=O)=C1.O
InChi Code
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1
InChi Key
QTAOMKOIBXZKND-PPHPATTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $38

    Add

    50 mg

    $71

    Add

    100 mg

    $131

    Add

    250 mg

    $291

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Carbidopa is a peripherally restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.1 Carbidopa (100 mg/kg) pretreatment in dog increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.2 Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons.3 It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clark, W.G., Oldendorf, W.H., and Dewhurst, W.G. Blood-brain barrier to carbidopa (MK-486) and Ro 4-4602, peripheral dopa decarboxylase inhibitors. J. Pharm. Pharmacol. 25(5), 416-418 (1973).

    2. Deleu, D., Sarre, S., Ebinger, G., et al. The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle. Naunyn Schmiedebergs Arch. Pharmacol. 348(6), 576-581 (1993).

    3. Ogura, J., Miyauchi, S., Shimono, K., et al. Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. Biochem J. 474(20), 3391-3402 (2017).