An internal standard for the quantification of carbidopa
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Unlabeled Version(s)
23783Carbidopa (hydrate)
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Carbidopa-d3 (hydrate)

Item No. 34884

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-α-hydrazinyl-3,4-dihydroxy-α-methyl-benzenepropanoic-2,5,6-d3 acid, monohydrate
CAS Number
1276197-58-0
Molecular Formula
C10H11D3N2O4 • H2O
Formula Weight
247.3
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
OC(C([2H])=C1C[C@@](NN)(C)C(O)=O)=C(C([2H])=C1[2H])O.O
InChi Code
InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1/i2D,3D,4D;
InChi Key
QTAOMKOIBXZKND-INNGTCQHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    Product Description

    Carbidopa-d3 is intended for use as an internal standard for the quantification of carbidopa (Item No. 23783) by GC- or LC-MS. Carbidopa is a peripherally restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.1 Administration of carbidopa (100 mg/kg) prior to administration of L-DOPA in dogs increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.2 Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR).3 It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clark, W.G., Oldendorf, W.H., and Dewhurst, W.G. Blood-brain barrier to carbidopa (MK-486) and Ro 4-4602, peripheral dopa decarboxylase inhibitors. J. Pharm. Pharmacol. 25(5), 416-418 (1973).

    2. Deleu, D., Sarre, S., Ebinger, G., et al. The effect of carbidopa on the pharmacokinetics and metabolism of intravenously administered levodopa in blood plasma and skeletal muscle. Naunyn Schmiedebergs Arch. Pharmacol. 348(6), 576-581 (1993).

    3. Ogura, J., Miyauchi, S., Shimono, K., et al. Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. Biochem J. 474(20), 3391-3402 (2017).