A natural form of vitamin A
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Product Type

Biochemicals
Natural Products
Vitamins

Research Area

Cancer
Cell Death

Retinyl Palmitate

Item No. 23796

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
retinol hexadecanoate
CAS Number
79-81-2
Synonyms
  • all-trans Retinyl Palmitate
  • Vitamin A Palmitate
Molecular Formula
C36H60O2
Formula Weight
524.9
Purity
≥95%
Formulation (Request formulation change)
A low-melting solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2): 0.3 mg/ml
λmax
327 nm
SMILES
CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
InChi Code
InChI=1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
InChi Key
VYGQUTWHTHXGQB-FFHKNEKCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Cayman Chemical
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    Product Description

    Retinyl palmitate is a natural ester form of vitamin A (Item No. 20241).1 It is a major storage form of vitamin A in vivo.2 Retinyl palmitate (1-100 µM) is cytotoxic to HeLa cells both alone and to a greater effect when combined with photodynamic therapy.3 It decreases tumor volume by 50% in a human gallbladder cancer mouse xenograft model when administered at doses of 1,000 or 2,500 IU/animal per day for three weeks and when administered prior to tumor implantation at a dose of 2,500 IU/animal.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCormick, A.M., and Napoli, J.L. Identification of 5,6-epoxyretinoic acid as an endogenous retinol metabolite. The Journal of Biological Chemisty 257(4), 1730-1735 (1982).

    2. O'Byrne, S.M., and Blaner, W.S. Retinol and retinyl esters: Biochemistry and physiology. J. Lipid. Res. 54(7), 1731-1743 (2013).

    3. Ibrahim, T., El Rouby, M.N., Al-Sherbini, e.-S.A., et al. Photodecomposition, photomutagenicity and photocytotoxicity of retinyl palmitate under He-Ne laser photoirradiation and its effects on photodynamic therapy of cancer cells <em>in vitro</em>. Photodiagnosis Photodyn.Ther. 13, 316-322 (2016).

    4. Li, C., Imai, M., Yamasaki, M., et al. Effects of pre- and post-administration of vitamin A on the growth of refractory cancers in xenograft mice. Biol. Pharm. Bull. 40(4), 486-494 (2017).