An antifungal agent
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Labeled Version(s)
34010Butenafine-13C-d3 (hydrochloride)
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Butenafine (hydrochloride)

Item No. 23797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-(1,1-dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine, monohydrochloride
CAS Number
101827-46-7
Molecular Formula
C23H27N • HCl
Formula Weight
353.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
CN(CC1=CC=C(C(C)(C)C)C=C1)CC2=C3C(C=CC=C3)=CC=C2.Cl
InChi Code
InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H
InChi Key
LJBSAUIFGPSHCN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $54

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    500 mg

    $102

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    1 g

    $190

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    Cayman Chemical
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    Product Description

    Butenafine is a benzylamine antifungal agent that has broad-spectrum activity against 87 strains of dermatophytes (MICs = 0.0015-0.05 µg/ml), 15 strains of Aspergillus (MICs = 0.025-0.78 µg/ml), 4 strains of Cryptococcus (MICs = 0.78-1.56 µg/ml), and 67 strains of Candida (MICs = 3.13 to >100 µg/ml).1 It acts by inhibiting squalene epoxidase.2 Butenafine (50 µM) inhibits the synthesis of ergosterol (Item No. 19850), a sterol in the cell membranes of fungi. Formulations containing butenafine have been used in the treatment of tinea pedis, tinea corporis, and tinea cruris.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maeda, T., Takase, M., Ishibashi, A., et al. Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent. Yakugaku Zasshi 111(2), 126-137 (1991).

    2. Hiratani, T., Asagi, Y., and Yamaguchi, H. Studies on antifungal mechanism of action of butenafine hydrochloride. II. Comparison in the response to drug treatment between a wild-type strain and tolciclate-resistant mutant strains of Sporothrix schenckii. Nihon Ishinkin Gakkai Zasshi 32(2), 139-149 (1991).