A thiazide diuretic
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Methyclothiazide

Item No. 23799

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide
CAS Number
135-07-9
Synonyms
  • NSC 110431
Molecular Formula
C9H11Cl2N3O4S2
Formula Weight
360.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
ClC1=C(S(N)(=O)=O)C=C(S(N(C)C(CCl)N2)(=O)=O)C2=C1
InChi Code
InChI=1S/C9H11Cl2N3O4S2/c1-14-9(4-10)13-6-2-5(11)7(19(12,15)16)3-8(6)20(14,17)18/h2-3,9,13H,4H2,1H3,(H2,12,15,16)
InChi Key
CESYKOGBSMNBPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    25 mg

    $81

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    50 mg

    $128

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    Product Description

    Methylclothiazide is a thiazide diuretic.1 It inhibits norepinephrine- (Item No. 16673) and vasopressin-induced contractions of aortic rings isolated from spontaneously hypertensive rats at a concentration of 100 μM. Methylclothiazide reduces salt-induced increases in blood pressure in salt-sensitive but not salt-resistant rats without affecting body weight or heart rate.2 Formulations containing methylclothiazide have been used to treat hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Colas, B., Slama, M., Masson, H., et al. Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rat. Fundam. Clin. Pharmacol. 14(4), 363-368 (2000).

    2. Sasaki, S., and Buñag, R.D. Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J. Cardiovasc. Pharmacol. 5(3), 378-383 (1983).