A histamine H2 receptor antagonist
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Labeled Version(s)
31493Famotidine-13C-d3
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Famotidine

Item No. 23828

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-propanimidamide
CAS Number
76824-35-6
Synonyms
  • MK-208
  • YM-11170
Molecular Formula
C8H15N7O2S3
Formula Weight
337.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: slightly soluble
λmax
289 nm
SMILES
NS(NC(CCSCC1=CSC(NC(N)=N)=N1)=N)(=O)=O
InChi Code
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChi Key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    5 g

    $128

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    10 g

    $236

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    25 g

    $502

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    Product Description

    Famotidine is a histamine H2 receptor antagonist with a Ki value of 12 nM in fractionated guinea pig cerebral cortex membranes.1 It is selective for H2 over H1 and muscarinic receptors (Kis = 4 and 28 µM, respectively, in bovine cerebral cortex).2 Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells (IC50 = 0.6 µM).3 It also suppresses histamine-induced gastric acid secretion in dogs when administered orally and in anesthetized rats when administered intraduodenally (ID50s = 10 and 400 µg/kg, respectively).3 Formulations containing famotidine have been used in the treatment of ulcers, gastroesophageal reflux disease (GERD), and heartburn, as well as to decrease the risk of gastrointestinal toxicity associated with non-steroidal anti-inflammatory drugs (NSAIDs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gajtkowski, G.A., Norris, D.B., Rising, T.J., et al. Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex. Nature 304(5921), 65-67 (1983).

    2. Kubo, N., Shirakawa, S., Kuno, T., et al. Antimuscarinic effects of antihistamines: Quantitative evaluation by receptor-binding assay. Jpn. J. Pharmacol. 43(3), 277-282 (1987).

    3. Nagaya, H., Inatomi, N., and Satoh, H. Differences in the antisecretory actions of the proton pump inhibitor AG-1749 (lansoprazole) and the histamine H2-receptor antagonist famotidine in rats and dogs. Jpn. J. Pharmacol. 55(4), 425-436 (1991).