A neurotransmitter
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Acetylcholine (chloride)

Item No. 23829

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(acetyloxy)-N,N,N-trimethyl-ethanaminium, monochloride
CAS Number
60-31-1
Synonyms
  • ACh
Molecular Formula
C7H16NO2 • Cl
Formula Weight
181.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC(OCC[N+](C)(C)C)=O.[Cl-]
InChi Code
InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChi Key
JUGOREOARAHOCO-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $41

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    Product Description

    Acetylcholine is a neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors (AChRs) in the central and peripheral nervous systems.1 It mediates motor function at the neuromuscular junction but also has functions in the parasympathetic and sympathetic nervous systems. It is involved in learning and memory through actions at nicotinic AChRs in the CNS. The actions of acetylcholine are terminated primarily via the action of acetylcholinesterase, which breaks it down into acetate and choline. Acetylcholine (chloride) mimics the effects of acetylcholine and has been used to determine the function of acetylcholine in various biological processes.2,3 Acetylcholine (chloride) inhibits peptide aggregation of p53 mutants in vitro at micromolar concentrations.2 It increases alveolar fluid clearance in a dose-dependent manner and enhances Na+/K+-ATPase activity, effects which are blocked by atropine (Item No. 12008), in a mouse model of pulmonary edema.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tiwari, P., Dwivedi, S., Singh, M.P., et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac. J. Trop. Dis. 3(5), 413-420 (2013).

    2. Chen, Z., and Kanapathipillai, M. Inhibition of p53 mutant peptide aggregation in vitro by cationic osmolyte acetylcholine chloride. Protein Pept. Lett. 24(4), 353-357 (2017).

    3. Li, X., Yan, X.X., Li, H.L., et al. Endogenous acetylcholine increases alveolar epithelial fluid transport via activation of alveolar epithelial Na,K-ATPase in mice. Respir. Physiol. Neurobiol. 217, 25-31 (2015).

    Product Citations

    Ray, J.W., Sun, X., Cruz-Diaz, N., et al. Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague-Dawley rats. Physiol. Rep. 13(7), e70250 (2025).