A non-selective muscarinic acetylcholine receptor antagonist
Related Products
Analytical Standard(s)
32997Atropine
Labeled Version(s)
30734Atropine-d5
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Atropine

Item No. 12008

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(hydroxymethyl)-benzeneacetic acid, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS Number
51-55-8
Synonyms
  • DL-Hyoscyamine
  • Tropine tropate
Molecular Formula
C17H23NO3
Formula Weight
289.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 10 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C(C1=CC=CC=C1)CO)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2
InChi Code
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChi Key
RKUNBYITZUJHSG-SPUOUPEWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 mg

    $28

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    1 g

    $42

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    Product Description

    Atropine is a naturally occurring tropane alkaloid extracted from plants of the family Solanaceae including deadly nightshade (A. belladonna). It is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8).1 Atropine increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine receptor sites, and decreases bronchial secretions.2 It is classified as an anticholinergic (parasympatholytic) drug and commonly used to dilate the pupils, increase heart rate, reduce salivation and other secretions, and as an antidote against organophosphate poisoning.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Caulfield, M.P., and Birdsall, N.J.M. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol. Rev. 50(2), 279-290 (1998).

    2. Broadley, K.J., and Kelly, D.R. Muscarinic receptor agonists and antagonists. Molecules 6(3), 142-193 (2001).

    3. Grynkiewicz, G., and Gadzikowska, M. Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. Pharmacol. Rep. 60(4), 439-463 (2008).