A muscarinic acetylcholine receptor agonist
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Labeled Version(s)
33299Bethanechol-d6 (chloride)
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Bethanechol (chloride)

Item No. 23830

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium, monochloride
CAS Number
590-63-6
Synonyms
  • (±)-Bethanechol
  • Carbamyl-β-methylcholine chloride
  • NSC 30783
Molecular Formula
C7H17N2O2 • Cl
Formula Weight
196.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.1 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC(OC(N)=O)C[N+](C)(C)C.[Cl-]
InChi Code
InChI=1S/C7H16N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H-,8,10);1H
InChi Key
XXRMYXBSBOVVBH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $41

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    5 g

    $103

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    10 g

    $178

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    25 g

    $349

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    Product Description

    Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.1 It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC50 = 127 µM).2 Bethanechol increases basal tone of isolated porcine intravesical ureter (EC50 = 4.27 µM).3 It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.4 Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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