An anticholinergic agent
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Product Type

Biochemicals

Research Area

Neuroscience
Ophthalmology

Methylhomatropine (bromide)

Item No. 23832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-endo)-3-[(2-hydroxy-2-phenylacetyl)oxy]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane, monobromide
CAS Number
80-49-9
Synonyms
  • NSC 34399
Molecular Formula
C17H24NO3 • Br
Formula Weight
370.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C(O)C1=CC=CC=C1)O[C@H]2C[C@H]3CC[C@H]([N+]3(C)C)C2.[Br-]
InChi Code
InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?;
InChi Key
FUFVKLQESJNNAN-RIMUKSHESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $40

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    5 g

    $171

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    Product Description

    Methylhomatropine is an anticholinergic agent.1 It blocks spasm of rat and rabbit intestines induced by acetylcholine (Item No. 23829) ex vivo (ED50s = 0.052 and 0.011 mg/kg, respectively). Methylhomatropine slows intestinal transit of a charcoal meal in rats (ED50 = 27 mg/kg) and blocks salivary gland secretion in rabbits (ED50 = 0.16 mg/kg). It also induces mydriasis in mice when administered subcutaneously or orally (ED50s = 0.13 and 12 mg/kg, respectively). Formulations containing methylhomatropine have been used in the treatment of nausea, vomiting, and motion sickness.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cahen, R.L., and Tvede, K. Homatropine methylbromide; a pharmacological reevaluation. J. Pharmacol. Exp. Ther. 105(2), 166-177 (1952).