A dopamine receptor antagonist
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Molindone (hydrochloride)

Item No. 23841

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one, monohydrochloride
CAS Number
15622-65-8
Synonyms
  • EN 1733A
  • (±)-Molindone
Molecular Formula
C16H24N2O2 • HCl
Formula Weight
312.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
210, 255, 297 nm
SMILES
O=C1C2=C(NC(C)=C2CC)CCC1CN3CCOCC3.Cl
InChi Code
InChI=1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H
InChi Key
GQWNECFJGBQMBO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $219

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    1 g

    $307

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    5 g

    $1,095

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    Product Description

    Molindone is a dopamine receptor antagonist.1 It selectively inhibits radioligand binding to dopamine D2 receptors in rat brain homogenates (IC50s = 56 and >10,000 nM for D2 and D1 receptors, respectively), however, it inhibits radioligand binding to both D2 and D1 receptors in vivo (ED50s = 4.9 and 51 mg/kg, respectively). Molindone (0.4-0.8 mg/kg) reverses depression of dopamine neurons induced by D-amphetamine and apomorphine (Item No. 16094) and increases dopamine synthesis and dihydroxyphenylacetic acid levels in the striatum and olfactory tubercles in rats.2 It suppresses spontaneous locomotion and blocks conditioned avoidance responses in male mice and female rats.3 It inhibits climbing behavior in mice induced by the D2 receptor agonist bromocriptine (Item No. 14598).4 Molindone (0.3-5.6 mg/kg) increases error rates and reduces response rate in pigeons following learned acquisition.5 Formulations containing molindone have been used in the treatment of schizophrenia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Andersen, P.H. Comparison of the pharmacological characteristics of [3H]raclopride and [3H]SCH 23390 binding to dopamine receptors in vivo in mouse brain. Eur. J. Pharmacol. 146(1), 113-120 (1988).

    2. Bunney, B.S., Roth, R.H., and Aghajanian, G.K. Effects of molindone on central dopaminergic neuronal activity and metabolism: Similarity to other neuroleptics. Psychopharmacol. Commun. 1(4), 349-358 (1975).

    3. Rubin, A.A., Yen, H.C., and Pfeffer, M. Psychopharmacological profile of molindone. Nature 216(5115), 578-579 (1967).

    4. Balsara, J.J., Nandal, N.V., Gada, V.P., et al. Antagonism of bromocriptine-induced cage climbing behaviour in mice by the selective D-2 dopamine receptor antagonists, metoclopramide and molindone. Indian J. Physiol. Pharmacol. 30(1), 85-90 (1986).

    5. Poling, A., Cleary, J., Berens, K., et al. Neuroleptics and learning: Effects of haloperidol, molindone, mesoridazine and thioridazine on the behavior of pigeons under a repeated acquisition procedure. J. Pharmacol. Exp. Ther. 255(3), 1240-1245 (1990).