A muscarinic acetylcholine receptor antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Methylscopolamine (bromide)

Item No. 23862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
CAS Number
155-41-9
Synonyms
  • NSC 61809
  • NSC 120606
  • U-5036
Molecular Formula
C18H24NO4 • Br
Formula Weight
398.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(O[C@H]1C[C@H]([N+]2(C)C)[C@@H]3O[C@@H]3[C@H]2C1)[C@H](CO)C4=CC=CC=C4.[Br-]
InChi Code
InChI=1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1
InChi Key
CXYRUNPLKGGUJF-RAFJPFSSSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 mg

    $44

    Add

    1 g

    $80

    Add
    Product Description

    Methylscopolamine is an antagonist of muscarinic acetylcholine receptors (Kds = 0.25, 0.37, 0.23, 0.22, and 0.3 nM for M1-5 respectively).1 It inhibits oxotremorine-induced gastric ulcer formation and pupillary light reflex in rats (ED50s = 0.4 and 3.6 μg/kg, respectively).2 It also increases pupil diameter in rats with an ED200 value of 1.8 μg/kg. Formulations containing methylscopolamine have been used for the treatment of peptic ulcers, intestinal spasms, and motion sickness.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jakubík, J., Randáková, A., Zimčik, P., et al. Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors. Sci. Rep. 7, 40381 (2017).

    2. Daniotti, S., and Del Soldato, P. Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat. Br. J. Pharmacol. 82(2), 305-307 (1984).