A muscarinic acetylcholine receptor antagonist
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Methylscopolamine (bromide)

Item No. 23862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
CAS Number
155-41-9
Synonyms
  • NSC 61809
  • NSC 120606
  • U-5036
Molecular Formula
C18H24NO4 • Br
Formula Weight
398.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(O[C@H]1C[C@H]([N+]2(C)C)[C@@H]3O[C@@H]3[C@H]2C1)[C@H](CO)C4=CC=CC=C4.[Br-]
InChi Code
InChI=1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1
InChi Key
CXYRUNPLKGGUJF-RAFJPFSSSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $44

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    1 g

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    Product Description

    Methylscopolamine is an antagonist of muscarinic acetylcholine receptors (Kds = 0.25, 0.37, 0.23, 0.22, and 0.3 nM for M1-5 respectively).1 It inhibits oxotremorine-induced gastric ulcer formation and pupillary light reflex in rats (ED50s = 0.4 and 3.6 μg/kg, respectively).2 It also increases pupil diameter in rats with an ED200 value of 1.8 μg/kg. Formulations containing methylscopolamine have been used for the treatment of peptic ulcers, intestinal spasms, and motion sickness.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jakubík, J., Randáková, A., Zimčik, P., et al. Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors. Sci. Rep. 7, 40381 (2017).

    2. Daniotti, S., and Del Soldato, P. Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat. Br. J. Pharmacol. 82(2), 305-307 (1984).