A fungal metabolite
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Isomer(s)
29940Aszonapyrone A
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Sartorypyrone A

Item No. 23863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-(+)-3-[(2E,6E)-9-[(1R,3S)-3-(acetyloxy)-2,2-dimethyl-6-methylenecyclohexyl]-3,7-dimethyl-2,6-nonadien-1-yl]-4-hydroxy-6-methyl-2H-pyran-2-one
CAS Number
1452396-10-9
Synonyms
  • 20-O-Acetyl Sartorypyrone D
Molecular Formula
C28H40O5
Formula Weight
456.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC(O1)=CC(O)=C(C/C=C(C)/CC/C=C(C)/CC[C@H]2C(C)(C)[C@@H](OC(C)=O)CCC2=C)C1=O
InChi Code
InChI=1S/C28H40O5/c1-18(11-14-23-25(30)17-21(4)32-27(23)31)9-8-10-19(2)12-15-24-20(3)13-16-26(28(24,6)7)33-22(5)29/h10-11,17,24,26,30H,3,8-9,12-16H2,1-2,4-7H3/b18-11+,19-10+/t24-,26+/m1/s1
InChi Key
VDURTFXVMLMCFA-GISJPLNESA-N
Origin
Fungus/Neosartorya sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $222

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    1 mg

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    Product Description

    Sartorypyrone A is a meroditerpene metabolite produced by Neosartorya fungal species.1 It inhibits the growth of MCF-7 breast, NCI-H460 lung, and A375-C5 melanoma cancer cell lines (GI50s = 46.3, 37.3, and 21.5 μM, respectively). Sartorypyrone A inhibits growth of Gram-positive bacteria, including multidrug-resistant S. aureus (MIC = 32 μg/ml), and reduces the mass of S. aureus and B. subtilis biofilms in vitro.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eamvijarn, A., Gomes, N.M., Dethoup, T., et al. Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213). Tetrahedron 69(40), 8583-8591 (2013).

    2. Gomes, N.M., Bessa, L.J., Buttachon, S., et al. Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis. Mar. Drugs 12(2), 822-839 (2014).