A meroditerpene fungal metabolite with diverse biological activities
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Aszonapyrone A

Item No. 29940

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(1R,4aS,4bR,7S,8aR,10aS)-7-(acetyloxy)tetradecahydro-4b,8,8,10a-tetramethyl-2-methylene-1-phenanthrenyl]methyl]-4-hydroxy-6-methyl-2H-pyran-2-one
CAS Number
83103-08-6
Molecular Formula
C28H40O5
Formula Weight
456.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
CC(O[C@H]1CC[C@@]2(C)[C@](CC[C@]([C@@H]3CC4=C(O)C=C(C)OC4=O)(C)[C@]2([H])CCC3=C)([H])C1(C)C)=O
InChi Code
InChI=1S/C28H40O5/c1-16-8-9-23-27(6,20(16)15-19-21(30)14-17(2)32-25(19)31)12-10-22-26(4,5)24(33-18(3)29)11-13-28(22,23)7/h14,20,22-24,30H,1,8-13,15H2,2-7H3/t20-,22+,23+,24+,27+,28+/m1/s1
InChi Key
QZWJQNIIRYNONX-NEKODSHDSA-N
Origin
Fungus/Aspergillus sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34 μg/ml).3

    WARNING This product is not for human or veterinary use.