An M1 and M2 muscarinic acetylcholine receptor antagonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Dicyclomine (hydrochloride)

Item No. 23867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1,1'-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride
CAS Number
67-92-5
Synonyms
  • Dicycloverine
Molecular Formula
C19H35NO2 • HCl
Formula Weight
346.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
CCN(CC)CCOC(C1(C2CCCCC2)CCCCC1)=O.Cl
InChi Code
InChI=1S/C19H35NO2.ClH/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17;/h17H,3-16H2,1-2H3;1H
InChi Key
GUBNMFJOJGDCEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $22

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    1 g

    $37

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    Product Description

    Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively).1 It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; Item No. 14486) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively.2 Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kunysz, E.L., Michel, A.D., and Whiting, R.L. Functional and direct binding studies using subtype selective muscarinic receptor antagonists. Br. J. Pharmacol. 93(3), 491-500 (1988).

    2. Subissi, A., Brunori, P., and Bachi, M. Effects of spasmolytics on K+-induced contraction of rat intestine in vivo. Eur. J. Pharmacol. 96(3-4), 295-301 (1983).