A skeletal muscle relaxant
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Labeled Version(s)
33464Methocarbamol-d5
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Methocarbamol

Item No. 23870

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-methoxyphenoxy)-1,2-propanediol, 1-carbamate
CAS Number
532-03-6
Synonyms
  • AHR 85
  • Guaiacol Glyceryl Ether Carbamate
  • Guaiphenesin Carbamate
  • NSC 170960
Molecular Formula
C11H15NO5
Formula Weight
241.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (pH7.2) (1:30): 0.03 mg/mlDMSO: 16 mg/mlEthanol: 14 mg/ml
λmax
230, 273 nm
SMILES
COC1=C(OCC(O)COC(N)=O)C=CC=C1
InChi Code
InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14)
InChi Key
GNXFOGHNGIVQEH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    10 g

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    25 g

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    Product Description

    Methocarbamol is an orally bioavailable skeletal muscle relaxant.1 In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg.1,2 It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg.3 Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 μM, respectively).4 Formulations containing methocarbamol have been used to treat skeletal muscle spasms.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cymbalist, M.A., and Shapero, M. A comparative study of the effect of some centrally acting skeletal muscle relaxants in mice. J. Pharm. Pharmacol. 26(2), 109-112 (1974).

    2. Nevins, M.E., Nash, S.A., and Beardsley, P.M. Quantitative grip strength assessment as a means of evaluating muscle relaxation in mice. Psychopharmacology (Berl) 110(1-2), 92-86 (1993).

    3. Crankshaw, D.P., and Raper, C. Some studies on peripheral actions of mephenesin, methocarbamol and diazepam. Br. J. Pharmacol. 34(3), 579-590 (1968).

    4. Parr, J.S., and Khalifah, R.G. Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. The Journal of Biological Chemisty 267(35), 25044-25050 (1992).