A corticosteroid
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Isomer(s)
38880Beclomethasone Dipropionate
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Alclometasone Dipropionate

Item No. 23901

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7α-chloro-11β-hydroxy-16α-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
66734-13-2
Synonyms
  • ACM
  • Alclometasone 17,21-Dipropionate
  • SCH 22219
Molecular Formula
C28H37ClO7
Formula Weight
521.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.2 mg/ml
λmax
244 nm
SMILES
O=C1C=C[C@@]2(C)C(C[C@@H](Cl)[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(COC(CC)=O)=O)OC(CC)=O)=C1
InChi Code
InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1
InChi Key
DJHCCTTVDRAMEH-DUUJBDRPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Alclometasone dipropionate (ACM) is a corticosteroid.1 It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 μl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes.2 Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sengoku, T., Morita, K., Sakuma, S., et al. Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur. J. Pharmacol. 379(2-3), 183-189 (1999).

    2. Nishibe, Y., Hamataka, M., Hasegawa, T., et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system. Japan J. Pharmacol. 50(4), 435-443 (1989).