A glucocorticoid receptor agonist and prodrug form of beclomethasone 17-propionate
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Beclomethasone Dipropionate

Item No. 38880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-chloro-11β-hydroxy-16β-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
CAS Number
5534-09-8
Synonyms
  • BC-DP
  • BDP
  • Beclomethasone 17,21-dipropionate
Molecular Formula
C28H37ClO7
Formula Weight
521.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
240 nm
SMILES
C[C@@]12[C@@](OC(CC)=O)(C(COC(CC)=O)=O)[C@@H](C)C[C@@]1([H])[C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)Cl
InChi Code
InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1
InChi Key
KUVIULQEHSCUHY-XYWKZLDCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Beclomethasone dipropionate is a glucocorticoid receptor agonist and prodrug form of beclomethasone 17-propionate (Item No. 38884).1,2 Beclomethasone dipropionate is converted to beclomethasone 17-propionate or beclomethasone 21-propionate via esterases, which are subsequently hydrolyzed to beclomethasone (Item No. 33196).1 It binds to the glucocorticoid receptor (IC50 = 2.4 nM) and inhibits glucocorticoid receptor transrepression induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014), as well as induces transactivation of the glucocorticoid receptor, in CV-1 cells expressing the human receptor.2 Formulations containing beclomethasone dipropionate have been used in the treatment of asthma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, J.K., Moore, C.D., Ward, R.M., et al. Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J. Pharmacol. Exp. Ther. 345(2), 308-316 (2013).

    2. Tanigawa, K., Nagase, H., Ohmori, K., et al. Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters. Int. Immunopharmacol. 2(7), 941-950 (2002).