An adenosine A2B receptor antagonist
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PSB-1115 (potassium salt)

Item No. 23929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,3,6,9-tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid, monopotassium salt
CAS Number
409344-71-4
Molecular Formula
C14H13N4O5S • K
Formula Weight
388.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
238, 312 nm
SMILES
O=C1N(CCC)C(C(NC(C2=CC=C(S([O-])(=O)=O)C=C2)=N3)=C3N1)=O.[K+]
InChi Code
InChI=1S/C14H14N4O5S.K/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23;/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23);/q;+1/p-1
InChi Key
CJOWSBOERSTJAR-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $168

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    25 mg

    $370

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    Product Description

    PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM).1 It is selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively, and over the A3 receptor, which it inhibits only 14% at a concentration of 10 µM. PSB-1115 pre-treatment reduces relaxation of rat trachea induced by repeated dosing of the non-selective adenosine agonist NECA (Item No. 21420).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hayallah, A.M., Sandoval-Ramírez, J., Reith, U., et al. 1,8-Disubstituted xanthine derivatives: Synthesis of potent A2B-selective adenosine receptor antagonists. J. Med. Chem. 45(7), 1500-1510 (2002).

    2. Walaschewski, R., Begrow, F., and Verspohl, E.J. Impact and benefit of A2B-adenosine receptor agonists for the respiratory tract: Mucociliary clearance, ciliary beat frequency, trachea muscle tonus and cytokine release. J. Pharm. Pharmacol. 65(1), 123-132 (2013).