An orally bioavailable combination of a nucleoside analog and TPase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

TAS 102

Item No. 23932

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,α,α-trifluoro-thymidine mixt. with 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione, monohydrochloride
CAS Number
2300074-31-9
Molecular Formula
C10H11F3N2O5 • 1/2C9H11ClN4O2 • 1/2HCl
Formula Weight
435.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5 mg/ml
λmax
263 nm
SMILES
O=C(NC(C(C(F)(F)F)=C1)=O)N1[C@H]2C[C@H](O)[C@@H](CO)O2.O=C(NC(C(C(F)(F)F)=C3)=O)N3[C@H]4C[C@H](O)[C@@H](CO)O4.ClC5=C(CN6CCCC6=N)NC(NC5=O)=O.Cl
InChi Code
InChI=1S/2C10H11F3N2O5.C9H11ClN4O2.ClH/c2*11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7;10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h2*2,5-7,16-17H,1,3H2,(H,14,18,19);11H,1-4H2,(H2,12,13,15,16);1H/t2*5-,6+,7+;;/m00../s1
InChi Key
KTHXRTQHERFOMN-GIZOTSQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $63

    Add

    10 mg

    $118

    Add

    25 mg

    $257

    Add

    50 mg

    $454

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    TAS 102 is an orally bioavailable combination of the antimetabolite nucleoside analog trifluorothymidine (TFT; Item No. 21366) with the thymidine phosphorylase (TPase) inhibitor tipiracil (TPI; Item No. 23319).1 In vivo, TAS 102 inhibits tumor growth by 65.7 and 44.9% in HCT116 and KM12C colon cancer xenograft mouse models, respectively, when administered at a dose of 150 mg/kg per day for 14 days.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peters, G.J. Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies. Ther. Adv. Med. Oncol. 7(6), 340-356 (2015).

    2. Nukatsuka, M., Nakagawa, F., and Takechi, T. Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with oxaliplatin on human colorectal and gastric cancer xenografts. Anticancer Res. 35(9), 4605-4615 (2015).

    3. Nukatsuka, M., Nakagawa, F., Saito, H., et al. Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts. Anticancer Res. 35(3), 1437-1445 (2015).