A muscarinic receptor antagonist
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Cyclopentolate (hydrochloride)

Item No. 23944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(1-hydroxycyclopentyl)--benzeneacetic acid, 2-(dimethylamino)ethyl ester, monohydrochloride
CAS Number
5870-29-1
Synonyms
  • (±)-Cyclopentolate
Molecular Formula
C17H25NO3 • HCl
Formula Weight
327.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly Soluble
SMILES
O=C(OCCN(C)C)C(C1(O)CCCC1)C2=CC=CC=C2.Cl
InChi Code
InChI=1S/C17H25NO3.ClH/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17;/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3;1H
InChi Key
RHKZVMUBMXGOLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $86

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    25 mg

    $190

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    50 mg

    $306

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    Product Description

    Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively).1 It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively).2 Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lazareno, S., Buckley, N.J., and Roberts, F.F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cell. Mol. Pharmacol. 38(6), 805-815 (1990).

    2. Ishikawa, H., DeSantis, L., and Patil, P.N. Selectivity of muscarinic agonists including (±)-aceclidine and antimuscarinics on the human intraocular muscles. J. Ocul. Pharmacol. Ther. 14(4), 363-373 (1998).