An internal standard for the quantification of AGN 193109
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AGN 193109-d7

Item No. 23976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl-d7)-2-naphthalenyl]ethynyl]-benzoic acid
CAS Number
1216429-25-2
Molecular Formula
C28H17D7O2
Formula Weight
399.5
Purity
≥99% deuterated forms (d1-d7).
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
CC1(C)C2=C(C=C(C#CC3=CC=C(C(O)=O)C=C3)C=C2)C(C4=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C4[2H])=CC1
InChi Code
InChI=1S/C28H24O2/c1-19-4-11-22(12-5-19)24-16-17-28(2,3)26-15-10-21(18-25(24)26)7-6-20-8-13-23(14-9-20)27(29)30/h4-5,8-16,18H,17H2,1-3H3,(H,29,30)/i1D3,4D,5D,11D,12D
InChi Key
NCEQLLNVRRTCKJ-KPYMRHKVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $336

    Add
    Product Description

    AGN 193109-d7 is intended for use as an internal standard for the quantification of AGN 193109 (Item No. 23975) by GC- or LC-MS. AGN 193109 is an antagonist of retinoic acid receptors (RARs).1 AGN 193109 decreases expression of cytokeratin K5-8, 13, 14, 16, 17, and 19 genes, markers of retinoid action in ECE16-1 cells, when co-administered with TTNPB (Item No. 16144) but not when used alone. In vivo, AGN 193109 induces cleft palate or frontonasal dysplasia and eye malformations in fetuses of pregnant mice following a single oral dose of 1 mg/kg.2   

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Agarwal, C., Chandraratna, A.S., Johnson, A.L., et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. The Journal of Biological Chemisty 271(21), 12209-12212 (1996).

    2. Kochhar, D.M., Jiang, H., Penner, J.D., et al. The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events. Int. J. Dev. Biol. 42(4), 601-608 (1998).